Non-steroidal anti-inflammatory drugs (NSAIDs) have a bad side effect profile; they can cause gastrointestinal bleeding and there are detrimental effects on the heart in some user. Now, evidence assessed in a new Cochrane Report suggests that in general oral NSAIDs cause more harm than good. Despite an early lack of evidence for efficacy of topical NSAIDs, more recent research suggests that for some uses, a topical treatment may be better in terms of risk-benefit ratio than an oral NSAID. Evidence is not strong for benefits in treating back pain, headache, or neuropathic pain, however.
The topical topic of topical NSAIDs