Most pharmaceuticals work by binding to proteins and modulating their activity in some way, either inhibiting or stimulating them or preventing their natural substrate from interacting with them. A new way to study these interactions could help in the design of new treatments with fewer side-effects, according to scientists at the University of East Anglia, UK. “Designing novel drugs is a bit like finding the proper piece that fits into a jigsaw puzzle,” explains team leader Jesus Angulo. “Our novel approach allows us to now find the exact piece that matches the complementary shape and graphical content in a protein binding site." The approach is based on a novel nuclear magnetic resonance (NMR) spectroscopy technique - DEEP-STD NMR.
Piecing together new drugs