Nobel chemists

Three scientists share this year's Nobel Prize in Chemistry which has a distinctly biological flavor. Aaron Ciechanover and Avram Hershko of Technion, the Israel Institute of Technology, in Haifa, share the $1.3million prize money with Irwin Rose of the University of California, Irvine, for their discovery of ubiquitin-mediated protein degradation. These three researchers swam against the scientific tide of the early 1980s to find an answer to the question, "how does the cell break down its waste proteins?" Their questioning ultimately revealed one of the cell's most important cyclical processes with implications for our understanding of life and the treatment of disease.