Liquid drugs

Ionic liquids have commonly been touted as safer, more environmentally benign alternatives to toxic and flammable volatile organic solvents. They are usually made from bulky cation and anion pairs the energy of crystallization of which precludes them from forming a solid at room temperature so they remain liquid. Australian chemists have now demonstrated that by choosing a pharmaceutically active ion as one of the pair and a biocompatible base as the other component it is possible to make a liquid form of drug that is more stable and more soluble than the parent compound. Such ionic liquid drugs could be used in rapid transdermal delivery. They also side-step a significant problem of many solid, crystalline drugs in that being liquid and so amorphous there are no issues of active drugs degrading to less active polymorphic forms.