Bisphenol A is a synthetic compound with weak estrogenic properties and has been linked to concerns over reproduction and gender problems in wildlife. Most of the 1-2 billion kilograms produced annually in the US alone is in polycarbonate food containers, baby bottles, refillable water containers, CDs, and liners for food and drink cans. Opponents of its use claim that studies funded by chemical producers fail to consider low-dose, but chronic exposure on public health. Now, University of Missouri biologist Frederick vom Saal points to several reasons why low-dose studies have failed to find adverse effects. Writing in C&EN, Bette Hileman suggests that vom Saal's opinions ought to be taken into account and that "it is especially important that an unbiased panel with no conflicts of interest and with a detailed knowledge of the field evaluate the literature on BPA." Such a panel could consider the weight of evidence in regard to adverse effects and choose only valid studies that avoid vom Saal's concerns from which to draw conclusions.