US researchers have demonstrated that anti-inflammatory drugs, such as ibuprofen, aspirin and naproxen, might reduce the effectiveness of antidepressant and anxiolytic medications, the selective serotonin reuptake inhibitors, or SSRIs. SSRIs, which include the likes of fluoxetine, citalopram and sertraline, are widely used to treat clinical depression, obsessive-compulsive disorder and anxiety disorders. Paul Greengard, Jennifer Warner-Schmidt and colleagues at The Rockefeller University point out that this surprising discovery could have important implications for sufferers of such mental illnesses who also have inflammatory conditions or chronic pain.