Chemists in The Netherlands have for the first time identified and analyzed an enzyme comprising two interlocking rings - a catenane, in other words. There are no previously known examples of such supramolecular structures in biology, the team, led by Jasmin Mecinovic of Radboud University, in Nijmegen, reports. The amazing enzyme was identified in a microbial archeon from mudpots in smoking, volcanic fumaroles in Italy. These microbes obtain their energy by converting carbon disulfide intro hydrogen sulfide and carbon dioxide using the enzyme CS2hydrolase. Structural analysis showed that the enzyme has two forms - a single ring structure and the double-ring structure, locked together as hexadecameric catenanes.
Amazing enzyme goes Dutch