Aiming for PP1

The enzyme PP1, protein phosphatase 1, plays an important role in many diverse biochemical processes in the body and is involved in many diseases, including cancer. It is too ubiquitous to target for drug development because an agonist or antagonist will inevitably disrupt processes in addition to the one being targeted leading to untenable side effects and complications. Now, researchers at Brown University, have used spectroscopy and crystallography to help them focus on how PP1 interacts with specific proteins and so understand its behavior in particular systems that might allow highly targeted drugs to be designed for a given system or process to avoid interactions away from the disease site.